E635 — Disodium 5'-ribonucleotides
E635 (Disodium 5'-ribonucleotides), a flavor enhancer, is rated "watch": fine in moderation. A 50/50 mix of disodium inosinate and guanylate used to enhance umami. Same purine-derivative concern: people with gout should limit intake.
What is Disodium 5'-ribonucleotides?
A premixed 50/50 blend of disodium inosinate and disodium guanylate. Common in flavored snacks, instant noodles, stock cubes, and seasoning mixes. Always paired with MSG to amplify umami.
What does it do to the body?
Same purine-metabolism concern as the individual components: people with gout or hyperuricemia should limit intake. Not permitted in food for infants under 12 weeks.
What regulators say
EFSA assessed it as safe at current use levels. The FDA approves it as GRAS.
Risk rating: Watch
Mixed evidence or a specific concern (gut, allergy, or contested safety data). Not alarming, but worth keeping an eye on rather than eating without limit.